MetS also promotes a chronic inflammatory state characterized by elevated pro‐inflammatory cytokines such as interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), and leptin, which enhance tumor progression by activating cancer‐associated adipocytes (CAAs) and modulating the tumor microenvironment [36, 37]. This evidence concerns the gene IL6 and neoplasm.