NES and attention deficit-hyperactivity disorder: To further understand whether the role of SELENOT is specific in dopaminergic neurons, we additionally constructed Selenotfl/fl;Nestin-cre and Selenotfl/fl;Gfap-cre mice to knock out Selenot expression in the whole brain and astrocytes, respectively, and assessed ADHD-like behaviors in these mice (Appendix Figs. S3–S5).