Additionally, the AD KI mice can be crossed with CD34‐NOG‐hIL‐34 mice (NOG mice with IL‐34 transgene that develops human‐like microglia in the brain after HSC reconstitution), which will allow the studies of human amyloid pathology in the context of the adaptive human immune system and human microglia.27 The gene discussed is IL34; the disease is amyloidosis.