ROC analysis revealed that [TIMP-2]•[IGFBP7] and TIMP-2 had excellent predictive values (AUC > 0.9) for AKI from 0 to 4 h after ICU admission and good predictive values (AUC 0.75–0.9) for AKI from 6 h to day 1 after ICU admission (Table 2, Supplementary Fig. 2, 3). Here, TIMP2 is linked to acute kidney injury.