In the 25 patients who did not develop AKI, no significant increase was noted in the concentrations of urinary biomarkers, including [TIMP-2]•[IGFBP7], TIMP-2, IGFBP7, NGAL, and L-FABP, at any time point after ICU admission compared with the preoperative measurement. The gene discussed is LCN2; the disease is acute kidney injury.