No predicted damaging variants were identified in the coding regions of FBN1 (known to cause Marfan syndrome when mutated); however, a novel variant was found that is predicted to alter splicing in FBN1 (chr15:48780559:A>C, predicted splice donor gain), which was not carried by the SCAD proband. The gene discussed is FBN1; the disease is spontaneous coronary artery dissection.