The monogenic conditions are autosomal dominant CTDs, such as Marfan syndrome (FBN1 mutations encoding fibrillin 1), vascular Ehlers–Danlos syndrome (COL3A1 mutations encoding type 3 collagen) or Loeys–Dietz syndrome (TGFBR‐1 and ‐2 mutations encoding transforming growth factor β receptors 1 and 2, and SMAD3 mutations).15 This evidence concerns the gene FBN1 and Marfan syndrome.