Some studies have confirmed that cardiometabolic risk factors such as obesity, hypertension and hyperlipidemia not only increase the risk of cardiovascular disease but are also strongly associated with sleep problems such as sleep apnea and insomnia.[15–17] Sleep disorders can also affect metabolic health through a variety of mechanisms, including disrupted hormone production, insulin resistance, and an increased inflammatory response.[18–20] However, no relevant studies have been conducted to specifically examine the relationship between the CMI and the risk of developing sleep disorders. This evidence concerns the gene INS and sleep disorder.