Previous studies have shown that within a specific range, lipid accumulation products and the visceral adiposity index are associated with the onset of obstructive sleep apnea, suggesting that maintaining ideal lipid accumulation product and visceral adiposity index levels has potential clinical significance in reducing the risk of onset of obstructive sleep apnea.[24] Obesity leads to plasma and hepatic hyperlipidemia and the activation of inflammatory cytokines (TNF-α, IL-6, etc) and transcription factors.[25] These inflammatory factors are associated with sleep disorders. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.