ERG and acute myeloid leukemia: HNRNPH1 is located in chromosome band 5q35.3 (chr5:179,614,178-179,634,784, by genecards) and contains 13 exons, producing several alternative spliced transcripts.[5] It has been demonstrated that variation 2 is related with poorer tumor differentiation.[6]ERG gene is located in chromosome band 21q22.2 (chr21:38,367,261-38,661,783, by genecards) and comprises 12 exons encoding 2 isoforms, ERG1 and ERG2.[7,8] According to GEPIA2 analysis, the HNRNPH1 and ERG gene is most highly expressed in AML[9] (Fig. 1A, B).