The 1298A>C mutant genotype has also been reported to be associated with high plasma homocysteine levels.[16] However, it has been reported that the 1298A>C mutant genotype can be clinically associated with thrombosis only if it occurs simultaneously with the 677C>T mutation.[17] In our case, MTHFR 677 was normal, while MTHFR 1298 was a homozygous mutant. The gene discussed is MTHFR; the disease is Venous thrombosis.