Rarely, hypothyroidism may lead to rhabdomyolysis, characterized by the rapid destruction of skeletal muscle and release of myoglobin, creatine kinase (CK), urate, and electrolytes into the circulation.[2] Thyroid diseases can also affect the heart’s structure and function, with diastolic dysfunction being a common abnormality in hypothyroidism. This evidence concerns the gene MB and hypothyroidism.