RYR1 and scoliosis: It is characterized by slow or nonprogressive proximal limb skeletal muscle weakness and hypotonia, muscular atrophy,[1] and skeletal deformities such as hip dislocation, scoliosis, and foot deformities including talipes equinovarus and flat foot, etc.[2,3] The major gene mutation encoding the skeletal muscle ryanodine receptor (RYR1 on chromosome 19q13.1) is implicated in this disease,[4] which also results in susceptibility to malignant hyperthermia (MH), and reports an increased risk of MH in patients with CCD.[5,6] It is extremely rare for a pregnancy to be combined with CCD.