TNF and rheumatic disorder: In this case, younger age at diagnosis and absence of predisposing conditions makes atherosclerosis as unlikely diagnosis.[4,5] Medications for TAK include glucocorticoids, synthetic disease modifying anti-rheumatic diseases (DMARDs) (azathioprine, methotrexate, leflunomide, mycophenolate mofetil, cyclophosphamide), and biologic DMARDS (TNF inhibitors, tocilizumab).