During early mini-puberty, the ROC curve AUC was the greatest for T (AUC 1, P < .001), as the consequence of the chosen methods for defining CHH, followed by LH [AUC 0.99 (95% CI .99-1, P < .001)] and INHB [AUC 0.96 (95% CI .92-1, P < .001)]. The gene discussed is PLOD1; the disease is cartilage-hair hypoplasia.