In summary, this study investigated thepreventive effects of nobiletinon HFD-induced obesity-related muscle atrophy through bile acid regulation.Our findings demonstrated that nobiletin intervention significantlyinfluenced the bile acid synthesis pathway in the liver by upregulatingCYP7A1 expression and inhibiting the FGFR/FXR/ERK pathway. The gene discussed is NR1H4; the disease is obesity disorder.