This study aimed to investigatethe preventiveeffects of nobiletinon HFD-induced obesity-related muscle atrophy through bile acid regulation.Our findings demonstrated that nobiletin intervention significantlyaffected the bile acid synthesis pathway in the liver by upregulatingCYP7A1 expression and inhibiting the FGFR/FXR/ERK pathway. Here, NR1H4 is linked to obesity disorder.