CRP levels exceeded the established normal threshold of 5 mg/dL in all cohorts (medians ranged from 136 mg/dL [IQR, 56-213 mg/dL] for MN-MLH to 147 mg/dL [IQR, 93-226 mg/dL] for COVID-CS) (to convert CRP to mg/L, multiply by 10); however, no significant variations were observed across cohorts. This evidence concerns the gene CRP and Cowden syndrome 1.