The reliability and robustness of these results were further supported by the Leave-one-out analysis and Cochran's Q Test (P > 0.05).<h4>Conclusion</h4>The study establishes a certain causal link between iron status and thyroid cancer, indicating that transferrin saturation, serum ferritin and serum iron are associated with thyroid cancer incidence. This evidence concerns the gene TF and thyroid cancer.