Normalised enrichment scores (NES) with a false discovery rate of less than 1% identified 1/50 enriched gene sets in tumours with high expression of SP7, but none in tumours with low expression of SP7. The gene set enriched in high SP7 expressing tumours was the geneset that represents genes down-regulated by K-Ras activation (HALLMARK_KRAS_SIGNALLING_DN), with an NES of 1.58 (P = 0.0058) (Fig. 4C). Here, SP7 is linked to neoplasm.