SP7 and neoplasm: Similarly, low levels of cytoplasmic osterix expression were significantly associated with larger tumour size (χ2 = 6.220, d.f.=1, P = 0.013) and histological type (χ2 = 25.863, d.f.=4, P < 0.001) at the time of presentation using Pearson χ 2 test of association; data is shown in Table 1.