Additionally, prior studies have highlighted the protective, anti-inflammatory, and proliferative roles of NRG1 in neuroinflammatory diseases and various conditions, these include traumatic injury [25], LPC-induced focal demyelinating lesions [18], schizophrenia [26], psychosis [27], Stroke [28], autism [29], symptomatic epilepsy [30] and Alzheimer's disease [31], also, different tumors including lung cancer [32], breast cancer [33], esophageal squamous cell carcinoma [34]. This evidence concerns the gene NRG1 and Alzheimer disease.