Additionally, the expected direct positive relationship between NRG1 and lncRNA Ftx expression, previously identified in spinal cord injury (SCI) [22], was not replicated in our study, possibly need larger sample size These results emphasize the complex regulatory dynamics of non-coding RNAs in the pathogenesis of MS and NMO, further highlighting the intricate molecular mechanisms. Here, NRG1 is linked to neuromyelitis optica.