Fatty acid binding protein 4 (FABP4) is a lipid‐binding protein with a highly conserved fatty acid‐binding domain, capable of efficiently binding and transporting fatty acids.[20] FABP4 regulates lipid metabolism in tissues such as adipocytes, muscle, and liver, playing a crucial role, particularly in the oxidation and storage of fatty acids.[21, 22, 23] However, the effects of obesity on myometrial contraction remain poorly understood, necessitating further multi‐level investigations to elucidate the underlying mechanisms. This evidence concerns the gene FABP4 and obesity due to melanocortin 4 receptor deficiency.