EIF2A and diabetes mellitus: Next, we recapitulated β cell loss resulting from cellular stress caused by genetic lesions or environmental insults in diabetes to validate the therapeutic effects of anisomycin, the eIF2α phosphorylation induced by O.E ZnT8 was subsequently inhibited (Figure S9m, Supporting Information), and β cell loss induced by O.E ZnT8 was also alleviated by anisomycin treatment (Figure S9n, Supporting Information).