WFS1 and Wolfram syndrome: In order to investigate pathogenic role of zinc transportation in stress induced cell death of β cell, we modeled that with WFS1‐LOF SC‐β cell, which represents the classic model of stress induced cell death by genetic lesion in T2D and Wolfram syndrome.[12, 13, 33, 34] Notably, by comparing DEGs between human type 2 diabetic β cells and nondiabetic β cells, as well as between WFS1 knockout and wild‐type (WT) SC‐β cells from our previous studies,[16, 28] we identified 223 genes that were significantly altered in both SC‐β and primary β cells.