Previous studies have shown that depletion of CAV1 in mice reduces LDL uptake.[42, 43] A lower protein level of CAV1 has been associated with the activation of receptor tyrosine kinase (RTK) pathways in breast cancer patients (n = 56), suggesting potential clinical relevance for these molecular events (Figure S8G, Supporting Information). The gene discussed is NTRK1; the disease is breast cancer.