Although there were no significant differences in the body weight between the O‐PCSK9 group and the EV group (Figure S4B, Supporting Information), overexpressing PCSK9 greatly increased the primary tumor weight by over 10‐fold and tumor size by ≈4.9‐fold compared to the empty vector group (Figure 4H, Figure S4C,D, Supporting Information). The gene discussed is PCSK9; the disease is neoplasm.