BGLAP and osteomyelitis: In Staphylococcus aureus (S. aureus) infected osteomyelitis models (Scheme 1B), PC‐OGP@TOB exhibited: (1) Bactericidal efficacy via dynamic TOB capture‐release, (2) Immunomodulatory activity by polarizing macrophages toward the M2 phenotype and inducing angiogenesis, and (3) The capsule promotes bone regeneration by synergistically upregulating collagen II and osteocalcin (OCN) to remodel the ECM microenvironment (Scheme 1C).