Importantly, the interaction between IM and HLA‐E*01:01 in increasing MS risk acts independently from the interaction between IM diagnosis and HLA‐DRB1*15:01 (a well‐known MS risk allele), as the association between IM and MS was strongest in individuals carrying both HLA‐E*01:01 and HLA‐DRB1*15:01 alleles. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.