USP28 and cardiac hypertrophy: Recent studies suggest that deubiquitinating enzymes (DUBs) contribute to the development of pathological cardiac hypertrophy.[33] We first analyzed the mRNA profiles of DUBs families in the hypertrophic myocardium of mice challenged with Angiotensin (Ang II), and found significant alterations in the gene expression of Otud1, Usp28, and Usp20 (Figure 1A).