USP20 and cancer: For example, a transcription factor Snail homolog 2 (SNAI2), which promotes metastasis, is a highly unstable protein through ubiquitin‐proteasome‐mediated degradation; USP20 stabilizes SNAI2 by deubiquitination, leading to breast cancer metastasis.[22] Furthermore, USP20 promotes cancer progression by inhibiting autophagy and enhancing cell proliferation.[24] However, the role of USP20 in cardiovascular diseases remains poorly characterized.