Neurotransmitters like glutamate, Calcitonin Gene-Related Peptide (CGRP), serotonin, γ-aminobutyric acid (GABA), substance P, and Neurokinin A play pivotal roles in both migraine attacks and migraines with aura, primarily triggered by cortical spreading depression (CSD) [5, 6]. Here, TAC1 is linked to migraine disorder.