MAPT and Alzheimer disease: Meanwhile, it has been reported that other pathological underlying causes, such as typical Alzheimer’s disease (AD) and Huntington’s disease (HD) pathology, including type 2 microtubule-associated protein (Tau) aggregation, and formation of polyglutamine might contribute to the onset of PD (Geddes et al., 1993; Kalia et al., 2015; Doherty et al., 2013).