RB1 and oropharynx cancer: Similarly, the radiosensitivity of human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) is partly attributed to deficient DNA repair caused by E6 and E7 viral oncoproteins, which degrade p53 and inactivate Rb, disrupting DNA repair pathways and enhancing susceptibility to radiation-induced DSBs (39, 40).