FANCA and Friedreich ataxia: Additionally, Xeroderma Pigmentosum (XP) is marked by extreme sensitivity to UV radiation due to defects in the NER pathway (21), while Fanconi Anemia (FA), characterized by mutations in FANCA and other FA genes, increases susceptibility to DNA crosslinking agents and radiation, demonstrating the role of DNA repair pathways in maintaining genomic stability (22).