TP53 and Immunodeficiency: This classification includes subtypes MCD (MYD88L265P and CD79B mutations), BN2 (BCL6 fusions and NOTCH2 mutations), N1 (NOTCH1 mutations), EZB (EZH2 mutations and BCL2 translocations), ST2 (PI3K signaling and JAK2 signaling), A53 (low p53 target genes), and TP53Mut (p53 signaling dysregulation, immune deficiency, and PI3K activation), each associated with different therapeutic responses and outcomes (150).