AIF1 and neoplasm: Fig. 2E,F represents another pair of adjacent tissue areas showing discrepant expression for the two microglia/macrophage markers, IBA1 and CD163. In Fig. 2E, IBA1 immunoreactivity is weak and very few recognisable microglia/macrophages are present. Fig. 2F demonstrates CD163 staining especially over tissue displaying reduced tissue integrity (necrosis)? . In contrast, in Fig. 2H immunoreactivity for CD163 is much weaker than that of IBA1 (Fig. 2G) in the corresponding tumor area (asterisk in Fig. 2H) but CD163 labeling is stronger than that for IBA1 towards the upper tumor margin (necrosis)?