TREX1 and neoplasm: In addition, a recent study by Ghosh et al. demonstrated that WT p53 in tumor cells recruits the ubiquitin ligase tripartite motif-containing 24 (TRIM24) to promote the Three-prime repair exonuclease (TREX1) degradation, leading to cytoplasmic DNA accumulation, activation of the cytoplasmic DNA-sensing cyclic GMP-AMP synthase/stimulator of interferon genes (cGAS/STING) pathway, induction of type I interferons (IFN-Is), and tumor suppressor effects [18].