These tumorigenic, fibroblast stimulation of exosomes released by p53-deficient colorectal cancer cells can be explained by up-regulation of multiple exosomal mirna, including miR-1249-5p, miR-6737-5p, and miR-6819-5p, which all target TP53 mRNAs [73]. This evidence concerns the gene TP53 and colorectal cancer.