AKT1 and colorectal cancer: For example, the ruthenium complex RXC has been shown to downregulate the expression of genes encoding the chaperone Hsp90 in HCT116 colorectal cancer cells, along with downstream effectors of Hsp90, including Akt1, Akt (pS473), mTOR (pS2448), 4EBP1 (pT36/pT45), GSK-3β (pS9) and NF-κB p65 (pS529).