We and others identified that target-derived BDNF is involved in the reorganization of CST axons (Bareyre et al., 2002; Vavrek et al., 2006; Ueno et al., 2012; Sato et al., 2025) and corticorubral axons following neonatal brain injury (Chang et al., 2022). This evidence concerns the gene BDNF and brain injury.