Abnormally low first trimester PlGF, especially in combination with other abnormal biomarkers such as pregnancy-associated plasma protein-A (PAPP-A), is associated with subsequent early preterm birth from preeclampsia or growth restriction.48,49 Given the multimodal nature of this first trimester screening approach, considerable reorganization efforts would be needed to deliver these benefits, and seem well-justified based on recent UK50 and Canadian51,52 reports. The gene discussed is PGF; the disease is preeclampsia.