Pregnant individuals who develop preeclampsia with severe features before 37 weeks of gestation typically have circulating PlGF levels less than 100 pg/mL, which is well below the 5th percentile at all viable gestational ages up to 36 weeks.9 They also exhibit high levels of sFlt1, with higher ratio levels proportional to fetal and maternal disease severity (reviewed recently27). This evidence concerns the gene PGF and preeclampsia.