25 Serial maternal blood analysis of PlGF and sFlt1 levels in the early second trimester are consistent with the molecular pathology; PlGF levels are 50% lower in pregnancies destined to deliver preterm with preeclampsia, while sFlt1 levels are unaffected at this stage.16 It is only in the later stages of disease progression, typically at >24 weeks’ gestational age, that sFlt1 levels become elevated.12,13. The gene discussed is PGF; the disease is preeclampsia.