The first criteria was set for adults by the specialists in Hashomer Medical Centre in 1997,[8,9] followed be criteria’s implemented for children diagnosis purposes in 2009.[10] Colchicine has been the primary treatment for FMF since 1972.[11] Colchicine is correlated to pyrin and acts by changing the organization of actin cytoskeleton through binding to tubulin monomers and preventing polymer formation.[12]. The gene discussed is MEFV; the disease is familial Mediterranean fever.