Once activated, it translocates to the nucleus and regulates DNA transcription.[13] STAT-3 has attracted significant research focus due to its crucial involvement in various biological processes, such as cell proliferation, differentiation, anti-apoptotic mechanisms, inflammatory responses, and angiogenesis.[14, 15, 16] Cytokines have been associated with the progression of RA, as demonstrated by a significant rise in pro-inflammatory cytokines such as TNF-α, and IL-6. The gene discussed is TNF; the disease is rheumatoid arthritis.