IL1B and obstructive sleep apnea syndrome: Common symptoms of OSA include intermittent hypoxia, hypoxemia, and disrupted sleep patterns.[2] Furthermore, intermittent hypoxia can stimulate the release of inflammatory markers such as tumor necrosis factor-κB, interleukin (IL)-6, and IL-1β, which can provoke a systemic inflammatory response.[3] It can be inferred that OSA is related to systemic inflammation and involves the activation of various cytokines.