TP53 and gastric cancer: In addition, inhibiting the expression of SWELL1 in gastric cancer cells not only suppresses cell proliferation and migration (Kurashima et al., 2021), but also leads to changes in the expression of a series of key signaling molecules, including genes related to the p53 signaling pathway (such as JNK, p53, and p21), B cell lymphoma 2 (Bcl-2), and Fas cell surface death receptor [FAS] (Sørensen et al., 2016; Kurashima et al., 2021) (Figure 2).