In-depth research has revealed that SWELL1 activates the cyclin D1/cyclin dependent kinase 2 (CDK2) signaling axis by binding to protein kinase C α (PKCa), while regulating HCC cell migration through the c-Jun N-terminal kinase (JNK) pathway (Lu et al., 2019) (Figure 2). This evidence concerns the gene CDK2 and hepatocellular carcinoma.