Clinical studies have shown that, compared to normal tissues, the expression levels of SWELL1 in pancreatic cancer (PAAD), hepatocellular carcinoma (HCC), esophageal cancer, colon cancer, and malignant glioma tissues are significantly increased (Rubino et al., 2018; Zhang et al., 2018; Konishi et al., 2019; Lu et al., 2019; Xu et al., 2022; Zhang et al., 2024). The gene discussed is LRRC8A; the disease is hepatocellular carcinoma.