CX3CR1 and neoplasm: For example, MMP9+ TAMs may play a role in tumor tissue remodeling (173–175), CX3CR1+ TAMs may exhibit unique phagocytic patterns (176, 177), ECM-associated TAMs (ECMMac) involved in extracellular matrix remodeling are upregulated (178, 179), and SPP1AREGMac exhibit distinct distribution within tumor tissues.