CD28 and neoplasm: A systemic NOD/SCID mouse model with established Raji tumors showed that UCB T cells expressing both CAR constructs exhibited significantly improved tumor control and reduced bioluminescence intensity compared with 4-1BB CAR and GFP controls, with bioluminescence intensity in the 4-1BB and CD28 accounting for one-third of the value in the 4-1BB group on day 8 (132).