NOS2 and infection: Additionally, mice deficient in myeloid ARNT/HIF-α signaling (LysMCreARNTf/f; missing both HIF-1α and HIF-2α pathways) infected with L. major exhibit decreased myeloid-derived NOS2 and VEGF-A which impairs lymphangiogenesis at the site of infection, resulting in larger lesion sizes, despite parasites being controlled (26).