We predict the upregulated genes are inhibited by HIF-α signaling (Slc26a11, Agap1, and Cxcr4) while the downregulated DEGs are mediated by HIF-α signaling (Mmgt1, Arhgap4, and Mdn1). Interestingly, Cxcr4 expression is downregulated during infection and pro-inflammatory stimulation in HIF-α competent macrophages compared to HIF-α competent infected macrophages (Table 3). Here, ARHGAP4 is linked to infection.