Furthermore, the immune infiltration analysis demonstrated that CRG cluster A had higher infiltration of immune cells such as activated CD8+ T cells and macrophages, which are known to be critical for anti-tumor immunity, compared to CRG cluster B. The differential immune infiltration between high-risk and low-risk groups provides insights into the prognostic value of CRGs in SKCM. This evidence concerns the gene CD8A and neoplasm.