STAT3 and neutropenia: These results confirm in a new cohort of patients that the altered immune cell profiles observed in patients with TαβCD8+ LGLL are primarily driven by STAT3 mutations (36); in addition, here we also show that these immune cell alterations go beyond the recurrently reported neutropenia (55, 56), since multiple other WBC compartments were affected in our cohort such as NK-cells, dendritic cells and, to a lesser extent also, basophils, in addition to the neutrophils.