Notably, SUSD3 was identified as a positive regulator of several critical processes in BRCA, including extracellular matrix structural components, IRE1-mediated unfolded protein responses, platelet activation, amoebiasis, nitrogen metabolism, protein digestion and absorption, and the synthesis of proteoglycans that contribute to the tensile strength of the extracellular matrix. The gene discussed is ERN1; the disease is amebiasis.