CD4 and cancer: Notably, SUSD3 expression was positively correlated with the infiltration of B cells, CAF cells, dendritic cells, CD4+ T cells, macrophages, CD8+ T cells, monocytes, NK cells, and Tregs cells in most tumor types, while it exhibited a negative correlation with the infiltration of MDSCs in cancers such as CHOL, GBM, LGG, PCPG, SRC, and SKCM (Figure 8).