The team led by Weijian Liu in China utilized scRNA-seq technology to characterize the immunosuppressive tumor microenvironment profile of osteosarcoma (OS) and discovered that MHC-I (HLA-A, HLA-B, and HLA-E)/B2M genes were downregulated, indicating diminished tumor immunogenicity in OS (59). This evidence concerns the gene HLA-E and neoplasm.