However, Natasja and his colleagues isolated γδT cells from 5 mismatch repair-deficient (MMR-d) colon cancer tissue for scRNA-seq, revealing that PD-1, activation, proliferation and killer genes expressed by γδ1 and γδ3 T cells were significantly upregulated in B2M-deficient tumors (64). The gene discussed is B2M; the disease is malignant colon neoplasm.