B2M and neoplasm: Nevertheless, tumor cells typically exhibit low or no expression of B2M/MHC-I, engendering the deprivation of the B2M/MHC-I/KIRs interaction and subsequently inducing NK cell activation, a process denominated as “missing self-recognition.” A study revealed that, the downregulation of B2M expression (approximately 9.8%) among NSCLC patients was correlated with an augmented infiltration of NK cells (99).