CCR1 and experimental autoimmune encephalomyelitis: Deletion of the CCR1 gene results in partial disease protection in the MS mouse model. CCR1 antagonist ameliorates experimental autoimmune encephalomyelitis by inhibiting Th9/Th22-related markers in the brain and periphery (SJL/J) (99). In patients, CCR1 was detected on were detected on mononuclear cells and macrophages in demyelinating plaques (100).