CCR2 KO mice did not illustrate CNS histopathology or clinical EAE (MOG induced in B6129PF2/J or C57BL/6J mice) and showed an obvious decrease in infiltrating T cells compared with control mice. CCR2 KO mice failed to develop EAE (59, 101). In patients, CCR2 was detected on infiltrating monocytes, macrophages and lymphocytes in MS lesions (54, 102). Here, MOG is linked to myeloid sarcoma.