CCR5 KO mice did not protect against EAE. KO mice (B6129PF2/J genetic background) exhibited milder EAE with less severe T-cell infiltration and demyelination in the spinal cord compared with controls (51, 63, 107). A CCR5 receptor antagonist and antibodies to CCL20 have been reported to diminish disease severity (53, 54). In patients, CCR5 was detected on lymphocytic cells, macrophages, and microglia in actively demyelinating MS brain lesions and T cells expressing CXCR3 or CCR5 in CSF were increased (30). The gene discussed is CCR5; the disease is myeloid sarcoma.