Biallelic variants in <i>FARSA</i> or <i>FARSB</i> are associated with reduced cytoplasmic phenylalanyl-tRNA synthetase (FARS1) activity and underlie a multisystem syndrome characterized by growth limitation, developmental delay, brain calcifications, interstitial lung disease (ILD), and liver involvement. This evidence concerns the gene FARS2 and interstitial lung disease.