Following surgical resection, postoperative EV ANGPT2 and EV CEMIP levels decreased by 36% and 8.5%, respectively, in the LLC group, and by 40% and 4.6%, respectively, in the LCM group.<h4>Conclusion</h4>These findings emphasize the potential of ANGPT2 and CEMIP as biomarkers for LC progression and prognosis. This evidence concerns the gene ANGPT2 and laryngotracheoesophageal cleft.