Purinergic receptors are widely recognised for their therapeutic involvement in several disorders, including PD, Alzheimer’s disease, Multiple Sclerosis, Huntington’s disease, cancer, rheumatoid arthritis, and ischemia.4-7 Researchers investigated the function of extracellular adenosine triphosphate (ATP) in several cell types and origins of purinergic neurotransmission in 1976. Here, P2RX5 is linked to Parkinson disease.