HMOX1 and hepatocellular carcinoma: Studies have shown that NRF 2 can not only promote the synthesis and regeneration of GSH, maintain the level of GSH in HCC and reduce its consumption to play an antioxidant role; Moreover, it can counteract sorafenib induced ferroptosis by activating the expression of downstream antioxidant gene HO-1 (heme oxygenase-1) via p62-Keap 1-NRF 2 pathway (35).