The KLF6 gene (krüppel-like transcription factor 6), consisting of 3 DNA-binding zinc domains, regulates the cell cycle by inducing the expression of the cell cycle inhibitor p21 and preventing replication as its main function; however, KLF6 is a factor that can also be one of several modulators of cell differentiation, apoptosis and development and is therefore considered a tumor suppressor. This evidence concerns the gene KLF6 and neoplasm.