Furthermore, TNF-α levels in serum and knee articular cavity of the two groups were compared and it was found that after the intervention, TNF-α level was significantly lowered in the two groups, TNF-α level of the treatment group was lower than that of the control group, indicating that for gout patients with hyperuricemia, daily treatment with high-dose of 80 mg can reduce the level of inflammatory factors. This evidence concerns the gene TNF and gout.