TNF and rheumatoid arthritis: By regulating key targets such as Akt, MAPK, NF-κB, STAT3, HIF1α, JUN, FOS, TP53, and Multiple signaling pathway such as PI3K-Akt signaling pathway, AGE-RAGE signaling pathway, IL-17, TNF signaling pathway and HIF-1 signaling pathway plays a therapeutic role in RA.