TNF and rheumatoid arthritis: The GO enrichment results mainly involved: chemical stress, oxidative stress, reactive oxygen species, lipopolysaccharide cellular response, membrane rafts, membrane microdomains, membrane domains, nuclear receptors, ligand/transcription factor activities, DNA-binding transcription factors, etc. The KEGG results also showed that the therapeutic effect of QED on RA is mainly through: regulating lipid and atherosclerosis, cancer pathway, PI3K-Akt signaling pathway, AGE-RAGE pathway, IL-17, TNF and other inflammatory signaling pathways and HIF-1 signaling pathway.